R2H
Multi-agent evidence analysis for biomedical research

Clarisyn

The evidence is scattered across papers and databases. The answer shouldn't be.
Clarisyn uses multi-agent analysis to evaluate the literature, compute new results from biomedical data, and bring both into one decision-ready report.

Literature Access · Powered byConsensus

When does Clarisyn actually help?

Master's student

"What does the evidence actually say?"

PhD researcher

"This compound has no published data. What can I still learn about it?"

Computational biologist

"Which cell lines are most dependent on this target?"

Postdoctoral researcher

"Why do these findings disagree?"

Industry scientist

"Is this target worth pursuing?"

Medicinal chemist

"Where would this compound fail in development?"

Professor

"Does the data support that conclusion?"

Research team

"Is this number measured, or predicted?"

Different people. Same moment.

That's when you open Clarisyn.

Step 1: Ask

Ask any biomedical question.

Clarisyn answers it from every angle the question needs, across published literature and experimental data.

Assess the toxicological risk of MX-2414 for human dietary exposure stratify by metabolic activation potential, CYP450 species differences, and propose a tiered testing strategy consistent with JECFA guidelines.
Target validationTarget dependencyMechanism of actionStructure & bindingPreclinical safetyToxicologyADME & BioavailabilityExpression signaturesEfficacy signalsBiomarker selectionPatient stratificationGo / No-go rationaleClinical translationCompetitive landscape+more
Step 2: Analyse

Multi-agent analysis in progress.

Automated · 30 min

Automated

Multi-agent analysis across literature and data.

Optional
Expert review · 24 hrs

Expert review

A domain expert validates the findings before delivery.

Step 3: Receive

Your decision-ready structured report. In three layers.

Layer 1· Intelligence Report

Intelligence Report, highlighting the key insights and actionable takeaways.CYP3A4-mediated inhibition at clinical exposure levels presents a low but non-negligible DDI risk. Based on available in vitro and in vivo data, dose adjustment guidance for co-administered substrates is warranted prior to Phase I initiation.Agent consensus: 2 of 3 agents flagged DDI risk as clinically actionable. 1 agent rated risk as low-moderate pending in vivo confirmation.

Layer 2· Reasoning & Process

Reasoning

Reasoning, scoring, and decision steps are shown in full for transparency.

Biological rationale and competitive intensity weighted across 7 criteria.

Each indication scored on a 1–5 scale per criterion, summed into a final weighted score.

Process

Intermediate steps are logged for full process transparency.

All reasoning steps are documented in a single file, with each agent's process clearly separated.

Full log: clarisyn_report_log.docx
Layer 3· Evidence & Sources

This analysis was built on 49 curated sources, synthesized across 200+ datasets spanning preclinical and clinical literature.

1
FDA Guidance, 2019· IND Safety Reporting (Regulatory)
2
Chen & Zhang, 2023· J. Tox. Sci. (PubMed)
3
ClinicalTrials.gov· NCT04736706 · Phase I DDI Study (ClinicalTrials)
4
PubChem CID 2723949· CYP3A4 binding affinity data (ChemDB)
...

What sets Clarisyn apart?

Every answer draws on academic papers, clinical trial registries, chemical databases and protein structures. No open web, so higher accuracy and lower hallucination risk.

ChEMBL
ACS
AlphaFold
ClinicalTrials.gov
OpenAlex
PubMed
Consensus
Database

When the answer isn't in a paper yet, Clarisyn runs its own analysis: dependency and viability datasets, expression signatures, structure prediction, docking.

Clarisyn

Specialised agents search, analyse and verify, then compare what they found. Agreements, conflicts and gaps are all shown in the report. Nothing is hidden, nothing is filled in.

Question
Literature
agent
⟷
Computational
agent
Verification engine
One report

Reports can be shared, annotated, and discussed with your team. When a second opinion matters more than a second look, an independent expert can review it: professors, MDs, PhD researchers, without leaving the platform.

Collaborate
AK
MB
TS

Can we rerun this with updated tox data?

Expert review
MD
PhD
Prof

A layered report, shaped with scientists: the answer, the reasoning, the sources. Why each piece of evidence was trusted, ranked or rejected is always visible.

Is the hepatotoxicity signal observed in rats clinically relevant in humans?